Research

Veena S. Patil

M. Sc.
University of Agricultural Sciences, Dharwad, Karnataka, India

Ph. D.
Temasek Life Sciences Laboratory, Singapore (PhD awarded by Nanyang Technological University, Singapore)

Past Affiliations Post Doctoral training
Sanford Burnham Prebys Medical Discovery Institute (SBPMDI), La Jolla, USA.
University of California San Diego (UCSD), USA
La Jolla Institute for Immunology (LJI), La Jolla, USA

Email

veena@nii.ac.in


Research Interest

Human immunology, Infectious diseases, Non-coding RNAs, Stem cells. 

Summary of Research

T cell immune memory and infectious diseases

The acquisition of immunological memory to infections is a hallmark of protective immunity and hence forms the basis for vaccinations. During this evolutionarily conserved process of T cell immunological memory development, the naive T cells that have not previously encountered antigen, differentiate during the primary infection into memory T cells that have specialized functions in immune defense to a later infection with the same pathogen. Each pathogen elicits a specialized memory subset and once formed this specialized T cell memory can provide life-long immunity to the same pathogen. My lab is mainly interested in understanding how the T cell memory is formed during the primary infection and maintained over the years to defend the subsequent secondary infection from the same pathogen. For examples, currently our lab is focused on understanding the protective role ofCD4+ cytotoxic memory T cells in viral infections (dengue virus, cytomegalovirus, EBV) and various CD4+ T helper memory subsets in bacterial infection (Mycobacterium tuberculosis). Broadly, our research goal is to understand the biology of such specialized memory subsets and utilize this knowledge in designing and developing strategies to boost durable immune responses following therapeutics and vaccination against these pathogens.

We are a lab of immunogenomics and mainly use immunological and genomics tools along with molecular and cell biological tools, to address questions related to immune responses to infectious disease in humans.

Funding: The lab is funded by Wellcome-Trust DBT India Alliance and NII. 

Open positions

We are looking to hire enthusiastic JRFs, psotdocs, and research associates. Interested candidates please send in CV along with brief write up on your research interests through email.

Selected Publications

  • *Zhang Q, *ChaoT, *Patil VS, Qin Y , Tiwari SK , Chiou J , Dobin A, Tsai C, Li1 Z , Dang J , Gupta S, Urdah K , Nizet V, Gingeras TR, Gaulton K and Rana TM. 2019. The long noncoding RNA ROCKI regulates inflammatory gene expression.  Embo J(*Joint 1st author). DOI 10.15252/embj.2018100041
  • Patil VS, Madrigal A, Schmiedel BJ, Clarke J, O'Rourke P, deSilva AD, Harris E, Peters B, Seumois G, Weiskopf D, SetteA and Vijayanand P, 2018. Precursors of human CD4+ cytotoxic T lymphocytes identified by single-cell transcriptome analysis. Science Immunology 3, eaan8664 (2018).(Featured article rotate).
  • Tian Y, Babor M, Lane J, Schulten V, Patil VS, Seumois G, Burel J, De Silva AD, Premawansa S, Premawansa G, Wijewickrama A, Vijayanand P, Weiskopf D, Sette A, Peters B. 2017. Unique phenotypes and clonal expansions of human CD4 effector memory T cells re-expressing CD45RA. Nature Communications 8, 1473 (DOI: 10.1038/s41467-017-01728-5).
  • Dang J, Tiwari, SK, Gianluigi Lichinchi, Yue Qin, Patil VS, Alexey M. Eroshkin, and Tariq M. Rana. 2016. Zika Virus Depletes Neural Progenitors in Human Cerebral Organoids through Activation of the Innate Immune Receptor TLR3. Cell Stem Cell 19, 1–8, July 7, 2016.
  • *Patil VS,*Anand A, Chakrabarti A, and Kai T. 2014. The Tudor domain protein Tapas, a homolog of the vertebrate Tdrd7, functions in the piRNA pathway to regulate retrotransposons in germline of Drosophila melanogaster. BMC Biology, 12:61 (*Joint 1st author) Comments in: Yang Z and Pillai RS. 2014. Fly piRNA biogenesis: tap dancing with Tej. BMC Biology, 12:77.
  • *Sakurai K, *Talukdar I, *Patil VS, Dang J, Li Z, Chang KY, Lu CC, Delorme-Walker V, Dermardirossian C, Anderson K, Hanein D, Yang CS, Wu D, Liu Y, Rana TM. 2014. Kinome-wide functional analysis highlights the role of cytoskeletal remodeling in somatic cell reprogramming. Cell Stem Cell. 2014;14(4):523-34 (*Joint 1st author) Comments in: David L, Hirsch CL. 2014. How Tets and cytoskeleton dynamics MET in reprogramming. Cell Stem Cell. 2014 Apr 3;14(4):417-8.
  • Li Z, Chao TC, Chang KY, Lin N, Patil VS, Shimizu C, Head SR, Burns JC, Rana TM. 2014. The long noncoding RNA THRIL regulates TNFα expression through its interaction with hnRNPL. Proc Natl AcadSci U S A. Jan 21;111(3):1002-7.
  • Patil VS and Kai, T. 2010. Repression of Retroelements in the Drosophila Germline via piRNA Pathway by the Tudor Domain Protein Tejas. Current Biology 20: 734-730.
  • Patil VS, Zhou R, Rana TM. 2014. Gene regulation by non-coding RNAs.Crit Rev BiochemMol Biol. Jan-Feb;49(1):16-32.
  • *Pek, JW, *Patil VS and Kai, T. 2012. piRNA pathway and the potential processing site the nuage, in the Drosophila germline. Develop. Growth Differ. 54, 66–77. (*Joint 1st author).

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