Arnab Mukhopadhyay

M. Sc.
University of Delhi, India

Ph. D.
University of Delhi, India

Postdoctoral Research
University of Massachusetts Medical School, 
Worcester, MA, USA.



Research Interest

Longevity, Dietary restriction, Insulin-IGF-1 signalling pathway, metabolism, stress response, innate immunity, Genomics, Next generation sequencing

Group Members

Amit Garg, Gautam Sarkar, Tripti Nair, Umanshi Rautela, Biswajit Ghosh, Sabnam Sahin Rahim, Nikhita Anand, Aashish Pratap Singh Chauhan and Sonu Gupta

Visiting students : Animesh Kar, Nafees Ansari, Trishna Pani 

Summary of Research

The primary focus of my lab is to understand the molecular mechanisms that determine the longevity of an organism. The main interests of the lab are:

a) The biology of Dietary restriction
b) Deciphering the molecular links between aging and innate immunity
c) Regulation of the Insulin-IGF-1 signaling pathway
d) Screening for novel compounds that extend longevity

We use a combination of molecular biology, genomics, Next Generation sequencing and molecular genetics approaches in the lab. Caenorhabditis elegans is the system of choice for our studies due to its short and reproducible life span, low maintenance cost, amenability to high throughput molecular techniques as well as ease of genetic manipulation. Interestingly, the molecular makeup of the innate immune response pathways and those that regulate longevity are strikingly similar between vertebrates and invertebrates. Such conservations are a key to extrapolating the results obtained in our model system and validating them in mammals.

Awards / Fellowships

Elected Fellow, Indian National Science Academy (INSA), 2021.
SERB-Science Technology Award for Research (STAR) award, 2019
Elected Fellow, The National Academy of Sciences (NASI), India, 2019
Elected Member of Guha Research Conference (GRC) (2017)
National Bioscience Award for Career Development (2016), Department of Biotechnology, Govt. of India
Ramalingaswami Fellowship (2009-2014), Department of Biotechnology, Govt. of India

Selected Publications

  • Sreekanth V, Kar A, Kumar S, Pal S, Yadav P, Sharma Y, Komalla V, Sharma H, Shyam R, Sharma RD, Mukhopadhyay A, Sengupta S, Dasgupta U^, and Bajaj A^ (2020) Bile Acid Tethered Docetaxel‐based Nanomicelles Mitigate Tumor Progression through Epigenetic Changes. Angewandte Chemie International Edition (in press)
  • Goyala A, Baruah A and Mukhopadhyay A (2020) The genetic paradigms of dietary restriction fail to extend life span in cep-1(gk138) mutant of C. elegans p53 due to possible background mutations, PLoS One 15(11):e0241478. DOI:10.1371/journal.pone.0241478
  • Chamoli M*, Goyala A*, Tabrez SS*, Siddiqui AA, Singh A, Antebi A, Lithgow GJ, Watts JL and Mukhopadhyay A (2020) Polyunsaturated fatty acids and p38 MAPK pathway link metabolic reprogramming to cytoprotective gene expression during Dietary Restriction. Nature Communications 11 (1), 1-13. *Co-first author
  • Matai L*, Sarkar GC*, Chamoli M, Malik Y, Kumar SS, Rautela U, Jana NR, Chakraborty K^, Mukhopadhyay A^ (2019) Dietary restriction improves proteostasis and increases life span through Endoplasmic Reticulum hormesis. Proceedings National Academy of Sciences USA 116 (35) 17383-17392.*Co-first author, ^Co-senior authors
  • Kumar N and Mukhopadhyay A (2019) Using ChIP-based approaches to characterize FOXO recruitment to its target promoters. Methods in Molecular Biology 1890:115-130. DOI: 10.1007/978-1-4939-8900-3_10.
  • Verma S, Jagtap U, Goyala A, Mukhopadhyay A  (2018) A novel gene-diet pair modulates C. elegans aging. PLOS Genetics (DOI:10.1371/journal.pgen.1007608)
  • Tabrez SS, Datta Sharma R, Jain V, Siddiqui AA and Mukhopadhyay A (2017) Differential alternative splicing coupled to nonsense-mediated decay of mRNA ensures dietary restriction-induced longevity. Nature Communications (DOI: 10.1038/s41467-017-00370-5).
  • Maity S*, Rajkumar A*, Matai L*, Bhat A, Ghosh A, Agam G, Kaur S, Bhatt NR, Mukhopadhyay A^, Sengupta S^, Chakraborty C^ (2016) Oxidative homeostasis regulates response to reductive Endoplasmic Reticulum stress through translation control. Cell Reports 16, 851–865. *Co-first author, ^Equally contributing senior authors 
  • Singh A, Kumar N, Matai L, Garg A and Mukhopadhyay A (2016) A chromatin modifier integrates insulin/IGF-1 signalling and dietary restriction to regulate longevity. Aging Cell 15:694–705.
  • Kumar N^, Jain V*, Singh A*, Jagtap U, Verma S and Mukhopadhyay A^ (2015) Genome-wide endogenous DAF-16/FOXO recruitment dynamics during lowered insulin signalling in C. elegans. Oncotarget  6(39):41418-33. *Equal contributions, ^Corresponding authors
  • Golegaonkar S*, Tabrez SS*, Pandit A, Shalini S, JagadeeshaPrasad MG, Bansode S, Sampathkumar SG, Kulkarni MJ^ and Mukhopadhyay A.^ (2015) Rifampicin reduces Advanced Glycation End products and activates DAF-16 to increase life span in Caenorhabditis elegans. Aging Cell 14(3):463-73. doi: 10.1111/acel.12327.  *Co-first authors, ^Corresponding authors
  • Pandit A, Jain V, Kumar N, and Mukhopadhyay A. (2014) PHA‐4/FOXA‐regulated microRNA feed forward loops during Caenorhabditis elegans dietary restriction. Aging 6(10): 835-851.
  • Chamoli M, Singh A, Malik Y, Mukhopadhyay A. (2014) A novel kinase regulates Dietary Restriction-mediated longevity in C. elegans. Aging Cell 13(4):641-55. doi: 10.1111/acel.12218.
  • Ritter AD, Shen Y, Fuxman Bass J, Jeyaraj S, Deplancke B, Mukhopadhyay A, Xu J, Driscoll M, Tissenbaum HA, Walhout AJ. (2013) Complex expression dynamics and robustness in C. elegans insulin networks. Genome Res. 23(6):954-65.
  • Parker JA, Vazquez-Manrique RP, Tourette C, Farina F, Offner N, Mukhopadhyay A, Orfila AM, Darbois A, Menet S, Tissenbaum HA, Neri C. (2012) Integration of ß-catenin, sirtuin, and FOXO signaling protects from mutant huntingtin toxicity.  J Neurosci 32:12630-40.
  • Padmanabhan S*, Mukhopadhyay A*, Narasimhan S*, Tesz G, Czech MP, Tissenbaum HA (2009) A PP2A regulatory subunit, PPTR-1, regulates C. elegans insulin signaling by modulating AKT-1 phosphorylation. Cell1 36:939-951.*Co-first author paper
  • Mukhopadhyay A*, Deplancke B*, Walhout AJM, Tissenbaum HA (2008) Chromatin immunoprecipitation (ChIP) coupled to detection by quantitative real-time PCR to study transcription factor binding to DNA inCaenorhabditis elegans. Nature Protocols 3:698-709. *Co-first author paper
  • Mukhopadhyay A, Pan X, Lambright D, Tissenbaum HA (2007) An endocytic pathway as a target of tubby for regulation of fat storage. EMBO Reports 8:931-938.
  • Deplancke B, Mukhopadhyay A,  Ao W, Elewa AM, Grove CA, Martinez NJ, Sequerra R, Doucette-Stamm L, Tissenbaum HA, Mango SE, Walhout AJM (2006) A gene-centered C. elegans protein-DNA interaction network. Cell 125:1193-205.
  • Oh SW*, Mukhopadhyay A*, Dixit BL, Raha T, Green MR, Tissenbaum HA (2006) Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation. Nature Genetics 38:251-257. *Co-first author paper
  • Mukhopadhyay A, Deplancke B, Walhout AJM, Tissenbaum HA (2005) C. elegans tubby regulates life span and fat storage by two independent mechanisms. Cell Metabolism 2:35-41.
  • Oh SW, Mukhopadhyay A, Svrzikapa N, Jiang F, Davis RJ, Tissenbaum HA (2005) JNK regulates life span in C. elegans by modulating nuclear translocation of FOXO/DAF-16. Proceedings National Academy of Sciences USA 102:4494-4499.

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