Research

Devram Ghorpade

Dr. Devram Ghorpade

M.Sc.
University of Pune, India

Ph.D.
Indian Institute of Science, Bangalore, India

Postdoctoral Research
Columbia University, New York, USA.

Email
dev@nii.ac.in

 

Research Interest

The correlation between obesity-associated bio-hormonal disturbances and inflammatory bowel disease (IBD)

Group Members

G.S. Neelaram, Vineet Singh and Shipra Sankla

Summary of Research

Inflammatory bowel disease (IBD) is an idiopathic disease which is a combination of two sets of pathologies; chronic inflammation of the entire gastrointestinal tract (Crohn’s disease; CD) and inflammation of the colon (Ulcerative colitis; UC). Diet-induced obesity and associated metabolic-cellular disturbances is one of the risk factors for the development of IBD. The modernization of lifestyle with increased intake of fat-enriched foods has significantly increased the incidences of obesity-associated IBD in developing countries like India. Although, the parallel rise in obesity and IBD have been well documented, the causative relationship between obesity and IBD is far from understanding. This limits the development of target-specific therapeutic to contain the incidences of IBD in obese individuals. The overall goal of our laboratory research is:

1. to identify previously unknown secretory plasma factors in the settings of obesity and their molecular-signaling networks that contribute to the development of IBD, and

2. to understand the functional role of diet induced microbial dysbiosis in the pathogenesis of IBD.

Selected Publications

  • Ghorpade D.S., Ozcan L.*, Zheng Z., Nicoloro S.M., Shen Y., Chen E., Blüher M., Czech M.P., Tabas I.* 2018. Hepatocyte-secreted DPP4 in obesity promotes adipose inflammation and insulin resistance. Nature.;555(7698):673-677. *equal corresponding author.
  • Ozcan L.*, Ghorpade D.S., Zheng Z., de Souza JC., Chen K., Bessler M., Bagloo M., Schrope B., Pestell R., Tabas I.* 2016. Hepatocyte DACH1 is increased in obesity via nuclear exclusion of HDAC4 and promotes hepatic insulin resistance. Cell Reports; 15(10):2214-25. *equal corresponding author.
  • Subramanian M.*, Ozcan L., Ghorpade D.S., Ferrante AW Jr., Tabas I. 2015. Suppression of adaptive immune cell activation does not alter innate immune adipose inflammation or insulin resistance in obesity. PLoS One.; 10(8):e0135842. *corresponding author. (citations = 14).
  • Ozcan L.*, Xu X., Deng S.X., Ghorphade D.S., Thomas T., Cremers S., Hubbard B., Serrano-Wu M.H., Gaestel M., Landry D.W., Tabas I.* 2015. Treatment of obese insulin-resistant mice with an allosteric MAPKAPK2/3 inhibitor lowers blood glucose and improves insulin sensitivity. Diabetes.; (10):3396-405. *equal corresponding author.
  • Fredman G., Kamaly N., Spolitu S., Milton J., Ghorpade D.S., Chiasson R., Kuriakose G., Perretti M., Farokzhad O.*, Tabas I.* 2015. Targeted nanoparticles containing the proresolving peptide Ac2-26 protect against advanced atherosclerosis in hypercholesterolemic mice. Science Translational Medicine. 7(275):275ra20. *equal corresponding author.
  • Holla S., Ghorpade D.S., Singh V., Bansal K., and Balaji K.N. 2014. Mycobacterium bovis BCG promotes tumor cell survival from tumor necrosis factor-alpha-induced apoptosis. Molecular cancer. 13(1):210.
  • Ghorpade D.S., Sinha A.Y., Holla S., Singh V. and Balaji K.N. 2013. NOD2-nitric oxide-responsive microRNA-146a activates Sonic hedgehog signaling to orchestrate inflammatory responses in murine model of inflammatory bowel disease. Journal of Biological Chemistry; 288(46):33037-48.
  • Ghorpade D.S., Holla S., Sinha A.Y., Alagesan S.K. and Balaji K.N. 2013. Nitric oxide and KLF4 protein epigenetically modify class II transactivator to repress major histocompatibility complex II expression during Mycobacterium bovis bacillus Calmette-Guerin infection. Journal of Biological Chemistry; 12;288(28):20592-606.
  • Ghorpade D.S., Holla S., Kaveri S.V., Bayry J., Patil S. A. and Balaji K.N. 2013. Sonic hedgehog-dependent induction of microRNA-31 and microRNA-150 regulates Mycobacterium bovis BCG driven TLR2 signaling. Molecular and Cellular biology. 33(3):543-56.
  • Ghorpade D.S., Leyland R, Kurowska-Stolarska M, Patil S.A., Balaji K.N. 2012. MicroRNA-155 is required for Mycobacterium bovis BCG mediated apoptosis of macrophages. Molecular and Cellular biology. 32(12):2239-2253.

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