About Us

Director

The focus of Dr. Sudhanshu Vrati’s research been on understanding the RNA virus replication, in particular the Japanese encephalitis virus, and the development of viral vaccine candidates.

Japanese Encephalitis virus (JEV) is a member of the Flaviviridae family of animal viruses that contains several other medically important viruses such as Dengue and Yellow fever. JEV is a major cause of human encephalitis and is responsible for considerable mortality and morbidity in India. Frequent epidemics of Japanese encephalitis (JE) are being reported from various parts of India and JEV has become endemic in several parts of the country. Dr. Vrati’s research group is studying the replication of JEV and investigating the role of the cellular proteins in virus replication. They are also examining the potential of small nucleic acid molecules such as siRNA and DNAzymes for inhibiting JEV replication.

Dr. Vrati’s group also focuses on key aspects of the JEV life-cycle like receptor-binding and entry mechanisms, molecular mechanisms of virus replication, assembly and egress. The virus infectious-cycle involves a complex interaction between virus and host proteins. They are employing JEV- recombinant proteins and infectious viruses as exploratory systems in combination with molecular biology, cell biology and proteomic approaches. These studies provide insight into JEV pathogenesis, and have the potential to offer therapeutic interventions.

In the recent years, Dr. Vrati’s group has focused on understanding the biology of Chikungunya virus with a view to develop novel antivirals. His laboratory has also been involved in the clinical development of an oral rotavirus vaccine for children and development of novel adenoviral vectors useful for vaccine delivery.

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